Humanin vs SHLP-6
Comparison of Humanin (Moderate evidence) and SHLP-6 (Low evidence).
Last updated: February 12, 2026
Humanin
SHLP-6
Overview
Humanin and SHLP-6 are both studied in the peptide research space.
Humanin: A 24-amino acid mitochondria-derived peptide (MDP) discovered in 2001 that shows cytoprotective, anti-apoptotic, and neuroprotective effects in preclinical studies.
SHLP-6: A 22-amino acid mitochondria-derived peptide with the unique property of being pro-apoptotic—the opposite of its sister peptides humanin and SHLP-2.
Evidence Comparison
| Aspect | Humanin | SHLP-6 |
|---|---|---|
| Evidence Level | Moderate | Low |
| Human Studies | 10 | 1 |
| Preclinical Studies | 40 | 11 |
| Total Sources | 50 | 12 |
Key Differences
| Aspect | Humanin | SHLP-6 |
|---|---|---|
| Category | Longevity | Longevity |
| Evidence Strength | Moderate | Low |
| Total Sources | 50 | 12 |
| Human Studies | 10 | 1 |
Summary
- Humanin: Moderate evidence with 50 total sources (10 human)
- SHLP-6: Low evidence with 12 total sources (1 human)
This comparison is for educational purposes only and is not medical advice. Consult a healthcare professional before making any decisions about peptide use.
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Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.