MOTS-c vs SHLP-2
Comparison of MOTS-c (Low evidence) and SHLP-2 (Low evidence).
Last updated: February 12, 2026
MOTS-c
SHLP-2
Overview
MOTS-c and SHLP-2 are both studied in the peptide research space.
MOTS-c: A 16-amino acid mitochondrial-derived peptide encoded in mtDNA that targets AMPK/mTOR pathways for metabolic regulation.
SHLP-2: A 26-amino acid mitochondria-derived peptide (MDP) discovered in 2016 from the same mitochondrial DNA region as humanin.
Evidence Comparison
| Aspect | MOTS-c | SHLP-2 |
|---|---|---|
| Evidence Level | Low | Low |
| Human Studies | 6 | 3 |
| Preclinical Studies | 22 | 17 |
| Total Sources | 35 | 20 |
Key Differences
| Aspect | MOTS-c | SHLP-2 |
|---|---|---|
| Category | Longevity | Longevity |
| Evidence Strength | Low | Low |
| Total Sources | 35 | 20 |
| Human Studies | 6 | 3 |
Summary
- MOTS-c: Low evidence with 35 total sources (6 human)
- SHLP-2: Low evidence with 20 total sources (3 human)
This comparison is for educational purposes only and is not medical advice. Consult a healthcare professional before making any decisions about peptide use.
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Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.