MOTS-c vs SHLP-6
Comparison of MOTS-c (Low evidence) and SHLP-6 (Low evidence).
Last updated: February 12, 2026
MOTS-c
SHLP-6
Overview
MOTS-c and SHLP-6 are both studied in the peptide research space.
MOTS-c: A 16-amino acid mitochondrial-derived peptide encoded in mtDNA that targets AMPK/mTOR pathways for metabolic regulation.
SHLP-6: A 22-amino acid mitochondria-derived peptide with the unique property of being pro-apoptotic—the opposite of its sister peptides humanin and SHLP-2.
Evidence Comparison
| Aspect | MOTS-c | SHLP-6 |
|---|---|---|
| Evidence Level | Low | Low |
| Human Studies | 6 | 1 |
| Preclinical Studies | 22 | 11 |
| Total Sources | 35 | 12 |
Key Differences
| Aspect | MOTS-c | SHLP-6 |
|---|---|---|
| Category | Longevity | Longevity |
| Evidence Strength | Low | Low |
| Total Sources | 35 | 12 |
| Human Studies | 6 | 1 |
Summary
- MOTS-c: Low evidence with 35 total sources (6 human)
- SHLP-6: Low evidence with 12 total sources (1 human)
This comparison is for educational purposes only and is not medical advice. Consult a healthcare professional before making any decisions about peptide use.
View Full Dossiers
Stay Updated on Peptide Comparisons
Get notified when we publish new comparison dossiers and evidence reviews.
No spam. Unsubscribe anytime.
Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.