SHLP-2 vs SHLP-6
Comparison of SHLP-2 (Low evidence) and SHLP-6 (Low evidence).
Last updated: February 12, 2026
SHLP-2
SHLP-6
Overview
SHLP-2 and SHLP-6 are both studied in the peptide research space.
SHLP-2: A 26-amino acid mitochondria-derived peptide (MDP) discovered in 2016 from the same mitochondrial DNA region as humanin.
SHLP-6: A 22-amino acid mitochondria-derived peptide with the unique property of being pro-apoptotic—the opposite of its sister peptides humanin and SHLP-2.
Evidence Comparison
| Aspect | SHLP-2 | SHLP-6 |
|---|---|---|
| Evidence Level | Low | Low |
| Human Studies | 3 | 1 |
| Preclinical Studies | 17 | 11 |
| Total Sources | 20 | 12 |
Key Differences
| Aspect | SHLP-2 | SHLP-6 |
|---|---|---|
| Category | Longevity | Longevity |
| Evidence Strength | Low | Low |
| Total Sources | 20 | 12 |
| Human Studies | 3 | 1 |
Summary
- SHLP-2: Low evidence with 20 total sources (3 human)
- SHLP-6: Low evidence with 12 total sources (1 human)
This comparison is for educational purposes only and is not medical advice. Consult a healthcare professional before making any decisions about peptide use.
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Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.