CJC-1295
Research OnlyAlso known as: DAC:GRF, Modified GRF 1-29, Tetrasubstituted GRF
A synthetic analog of growth hormone-releasing hormone (GHRH) with extended half-life. Limited clinical development; not approved for any indication.
Research Statistics
GHRH analog with Phase 1 human data; mechanism well-understood via GHRH receptor.
Research Dossier
Overview
What is CJC-1295 and what does the research say?
Mechanism of Action
CJC-1295 is a modified version of GHRH (growth hormone-releasing hormone) engineered for extended duration. The modifications confer resistance to enzymatic degradation and enable prolonged receptor activation.
How It Works (Simplified)
CJC-1295 stimulates growth hormone release through four key mechanisms:
Four amino acid substitutions at positions 2, 8, 15, and 27 prevent degradation by dipeptidyl peptidase IV, extending half-life from minutes to hours.
The DAC version contains maleimidoproprionic acid that covalently binds to serum albumin, extending half-life to 6-8 days.
Binds to GHRH receptors on pituitary somatotrophs, activating Gαs-adenylyl cyclase-cAMP-PKA signaling cascade.
Scientific Pathways
GHRH-R Signaling Pathway (GH Release)
CJC-1295 → GHRH-R binding → Gαs activation → Adenylyl cyclase
↓
↑ cAMP → PKA activation
↓
GH synthesis and secretionDAC Albumin Conjugation (Extended Half-Life)
CJC-1295 DAC → MPA group → Covalent binding to albumin Cys34
↓
Half-life extended to ~6-8 days
↓
Sustained GH/IGF-1 elevationKey Research: Teichman SL et al. (2006) demonstrated 2-10 fold GH elevation for 6+ days and IGF-1 elevation for 9-11 days in Phase 1/2 trials. PMID:16352683
Important Limitations
- Clinical development discontinued in 2006 after participant death (deemed unrelated to drug - pre-existing coronary disease)
- No approved indications in any country
- WADA prohibited substance
- Sustained vs pulsatile GH elevation may have different safety profiles
- Long-term effects of chronic IGF-1 elevation unknown
- Limited human clinical data due to early termination of development program
Evidence-Chained Benefits
Evidence-Chained Benefits
Research findings linked to mechanisms and clinical outcomes
What to Expect
Timeline based on observations from published studies. Individual responses may vary.
Based on Phase 1 data: Single injection of CJC-1295 DAC produced IGF-1 elevation within 24-48 hours. GH pulsatility patterns may begin to change. Steady-state levels not yet achieved.
Phase 1 studies showed sustained IGF-1 elevation lasting 9-11 days after single dose. With repeated dosing (weekly or twice-weekly), approaching steady-state levels. GH response patterns established.
Steady-state GH/IGF-1 elevations achieved with regular administration. In growth-deficient mouse models, normalization of growth occurred over this timeframe. Body composition changes may begin.
Limited long-term human data available. Animal studies suggest maintained efficacy. Clinical development was discontinued, so extended human timeline data is lacking.
Research-Based Observations
This timeline reflects observations from published clinical and preclinical studies. Individual responses may vary significantly. This is not a guarantee of effects or a dosing schedule. Consult qualified healthcare providers for personalized guidance.
Quality Checklist
Visual indicators to help evaluate CJC-1295 product quality
Good Signs (7 indicators)
Warning Signs (5 indicators)
Bad Signs (7 indicators)
For Research Evaluation Only
These quality indicators are general guidelines based on typical peptide characteristics. Professional laboratory testing (HPLC, mass spectrometry) provides definitive quality verification. This checklist is for initial visual evaluation only.
Peptide Interactions
Known and theoretical interactions when combining CJC-1295 with other peptides. Based on published research and mechanistic considerations.
Ipamorelin
SynergisticCommonly combined in research. CJC-1295 (GHRH analog) stimulates GH release via GHRH receptor while ipamorelin acts on ghrelin receptor. Different mechanisms may produce additive GH release.
GHRP-6
SynergisticGHRH + GHRP combination produces greater GH release than either alone. CJC-1295 amplifies GH pulse while GHRP-6 initiates it via ghrelin receptor.
GHRP-2
SynergisticSimilar synergistic mechanism as GHRP-6. GHRH and GHRP act through complementary pathways to enhance GH secretion.
MK-677
SynergisticCJC-1295 (GHRH pathway) and MK-677 (ghrelin pathway) may act synergistically. Different receptor targets produce complementary GH release.
Semaglutide
CautionGH can impair glucose tolerance. Monitor blood glucose if combining with diabetes medications.
Sermorelin
AvoidBoth are GHRH analogs acting on the same receptor. Combination provides no benefit and may cause receptor desensitization.
Tesamorelin
AvoidBoth are GHRH analogs with identical mechanism. No rationale for combining; use one or the other.
Research Note: Interaction data is based on published literature, mechanistic understanding, and theoretical considerations. Most peptide combinations lack direct clinical study. This information is for educational purposes only and does not constitute medical advice. Always consult qualified healthcare providers.
References
Key Studies Cited
Full reference list available on request. All citations link to PubMed for verification.
Methodology Note
This dossier synthesizes available evidence from peer-reviewed literature, regulatory documents, and clinical trial registries. Evidence strength ratings follow a modified GRADE approach.
For complete methodology details, see our Methodology page.
Important Disclaimer
This dossier is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.
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