What is CJC-1295?
An introduction to CJC-1295, a modified GHRH analog designed for longer-lasting effects. Learn about the two forms (with and without DAC) and why development was discontinued.
What is CJC-1295?
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that was modified to resist breakdown and last longer in the body. It was developed by ConjuChem Biotechnologies but never received FDA approval after clinical development was discontinued.
Key Facts
| Fact | Detail |
|---|---|
| FDA Approved | No |
| Development Status | Discontinued |
| Administration | Subcutaneous injection |
| WADA Status | Prohibited |
Two Forms Explained
| Version | Half-Life | Notes |
|---|---|---|
| CJC-1295 with DAC | ~8 days | Drug Affinity Complex extends duration |
| CJC-1295 no DAC | ~30 minutes | Also called “Mod GRF 1-29” |
The “with DAC” version binds to albumin in the blood, dramatically extending its active time. The version “without DAC” is essentially modified sermorelin with similar duration.
How Does It Work?
Like other GHRH analogs, CJC-1295 stimulates the pituitary gland to release growth hormone. The modification allows it to resist the enzyme DPP-IV that normally breaks down GHRH quickly.
The DAC version produces sustained GH elevation, while the non-DAC version produces more natural pulsatile release.
Research Status
What Studies Show
- Phase I/II trials showed significant GH and IGF-1 increases
- The DAC version raised IGF-1 levels for extended periods
- Some studies combined it with ghrelin mimetics
- Development was discontinued; reasons not publicly detailed
Evidence Level
Limited human data exists from early-phase trials. No completed Phase III trials. Long-term safety data is unavailable.
Important Warnings
- Neither version is approved for any use
- Available only from unregulated sources
- The DAC version may cause prolonged side effects
- Banned in competitive sports
This guide is for educational purposes only. CJC-1295 is not approved by any regulatory agency.
Sources & Citations
Disclaimer: This article is for educational purposes only and does not constitute medical advice. The information presented is based on current research but should not be used for diagnosis, treatment, or prevention of any disease. Always consult a qualified healthcare provider before making health decisions.