Ipamorelin vs CJC-1295
Comparison of two growth hormone-releasing peptides with different mechanisms and duration profiles.
Last updated: January 19, 2026
Ipamorelin
CJC-1295
Overview
Ipamorelin and CJC-1295 work through different receptor systems to stimulate growth hormone release. They are sometimes used in combination but neither is FDA-approved.
Mechanism Comparison
| Aspect | Ipamorelin | CJC-1295 |
|---|---|---|
| Receptor Target | Ghrelin/GHSR | GHRH receptor |
| Mechanism | GH secretagogue | GHRH analog |
| Natural Analog | Ghrelin-like | GHRH-like |
Selectivity Profile
| Effect | Ipamorelin | CJC-1295 |
|---|---|---|
| GH Release | Yes | Yes |
| Cortisol Effect | Minimal | Minimal |
| Prolactin Effect | Minimal | Minimal |
| Appetite Stimulation | Less than GHRP-6 | Minimal |
Duration of Action
| Parameter | Ipamorelin | CJC-1295 DAC | CJC-1295 no DAC |
|---|---|---|---|
| Half-life | ~2 hours | 5-8 days | ~30 minutes |
| GH Pattern | Pulsatile | Sustained | Pulsatile |
Evidence Quality
| Aspect | Ipamorelin | CJC-1295 |
|---|---|---|
| Human Trials | Phase 1/2 completed | Limited Phase 1 |
| Development Status | Discontinued | Discontinued |
| Evidence Level | Moderate | Moderate |
Combined Use
These peptides are sometimes used together, theoretically for synergistic GH release. However:
- No clinical trials of combination
- Safety not established
- Efficacy unproven
Regulatory Status
Both peptides:
- Are not FDA approved
- Are prohibited by WADA
- Have discontinued pharmaceutical development
- Are available only through unregulated sources
Summary
| Factor | Ipamorelin | CJC-1295 |
|---|---|---|
| Best for | Selective GH release | Sustained GH elevation (DAC) |
| Selectivity | High | N/A (different mechanism) |
| Human data | More available | Less available |
| Approval status | Not approved | Not approved |
This comparison is for educational purposes only. Neither peptide is approved by regulatory agencies.
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Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.